Z.L. BANDI and H.K. MANGOLD and G. HOLMER and E. AAES-JBRGENSEN

Febs Letters Vol. 12, N 4, 217:220, 1971

Abstract: Dietary long-chain alcohols and alkyl glycerols, including polyunsaturated compounds, are incorporated into the alkyl and alk-l-enyl moieties of the ionic alkoxylipids of rat liver, whereas polyunsaturated fatty acids are not.AGE-1971-печень крысы.pdf

HSIANG JU LIN, M.S.F. LIE KEN JIE, CLARA LAI HING LEE, and DANIEL HONG SENG LEE

LIPIDS, VOL. 12, N 7, 620:625, 1976

Abstract: A comparison of human adult and fetal adrenals with respect to their levels of glyceryl ether lipids and other lipid components is reported. Fetal glands contained significantly lower levels of alk-l- enyl phosphoglycerides and of choles- terol. Neutral glyceryl ether diesters, and ethanolamine and choline phosphoglycerides were isolated from adult adrenal tissue. The composition of the O-alkylglycerol groups in these lipid fractions was obtained by means of gas chromatography of the trimethylsilyl ethers and diacetyl derivatives; O-alk-l-enyl glycerols were analyzed as their diacetates. About one-half of the alkyl and alk-l-enylglycerol moieties present in glyceryl ether diesters contained hydrocarbon side chains with 20, 22, or 24 carbon atoms. Long hydrocarbon chains (C19-24) were also found in the O-alkyl glycerol moieties present in the total lipids of fetal adrenals.AGE-1977-надпочечн-человек.pdf

Glenn M. Smith and Corl Djerossi
LIPIDS, Vol. 22, N 4, 236:240, 1987

Abstract: The novel unesterified alkyl glycerol monoethers, (2S)-I-(hexadecyloxy)-2,3-propanediol (1), (2SM-(16-methylhepta-decyloxy}-2,3-propanediol (2) and (2S)-l-(15-methylhepta- decyloxy)-2,3-propanediol (3) were isolated from the marine sponge Tethya aurantia and were characterized by spectroscopic methods. These three saturated ethers as well as a series of alk-l'-enyl glycerol monoethers were also encountered in the phospholipids of the same sponge after reduction with LiAIH~. Incorporation experiments with dissociated cells of T. aurantia indicated that [1-'4C] - hexadecanol was incorporated into the unesterified alkylglycerol monoethers.AGE-1987-Губка-Djerassi.pdf

Merle L. Blank, Edgar A. Cress, Zigrida L. Smith and Fred Snyder
LIPIDS, Vol. 26, N 2, 166:169, 1991

Abstract: The goal of this investigation was to determine the effect of an alkylglycerol dietary supplement on the lipid composition of several major organs. Lipids from kidney, liver, and lung tissues of rats on a laboratory chow diet Icontrols) were compared to lipids from the same tissues of rats that had received oral supplements (300-600 mg/day} of 1-O-alkyl-2,3-diacetyl-sn-glycerol (alkyl groups were 65% 18:1 and 17% 16:1) for six days. Incorporation of the alkylglycerol into tissue lipids was indicated by both the presence of a neutral lipid in liver that had the same chromatographic migration as alkyldiacylglycerols and by a substantial increase (~150% of controls) in the octadecenyl group of the alk-l-enyl- and alkyl-glycerol side chains derived from total phospholipids of all three tissues. Compared to controls, there was a significant increase in the amount of alkylacylglycerophosphocholine in all three tissues of the alkylglycerol supplemented group. Total lipids, total phospholipid phosphorus, or the distribution of phospholipid classes (except for small differences in lung tissue) were not affected by the dietary supplement. The increase in ether lipids was offset by a corresponding decrease in the diacyl subclass in tissues from animals on the alkyldiacetylglycerol supplement. Our results indicate that the amount of ether-linked glycerolipids in rat tissues can be easily increased with dietary supplements of alkylglycerols.AGE-1991-Snyder-крыса.pdf